Naslov
GENETIC BACKGROUND OF TESTICULAR GERM CELL TUMORS: MODERN INSIGHT AND STANDARD TREATMENT

Autori
Vladušić, Tomislav ; Hrašćan, Reno ; Pećina-Šlaus, Nives ; Krušlin, Božo ; Vrhovac, Ivana ; Garaj-Vrhovac, Verica ; Franekić, Jasna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Symposia Abstract 24th FAPA Congress 2012 / - , 2012

Skup
24th FAPA Congress 2012

Mjesto i datum
Bali, Indonezija, 13.09.2012. - 16.09.2012

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
testicular germ cell tumors; seminoma; nonseminoma; loss of heterozygosity; microsatellite instability

Sažetak
Human testicular germ cell tumors (TGCTs) are histologically heterogenous neoplasms with variable malignant potential. Two main groups, seminomas and nonseminomas, differ biologically and clinically. Although found together in a patient, their development and evolution of clinical response is not fully understood. Despite high curability, cases of chemoresistance arise. To gain insight about the role of genetic background in development and clinical outcome of TGCTs, tissue samples were analysed for loss of heterozygosity (LOH) and microsatellite instability (MSI) within a set of genes involved in cell adhesion (CDH1, APC, NME1), cell cycle regulation(CDKN2A, RB1, TP53), DNA damage repair (BRCA1, MLH1, MSH2, RAD51), apoptosis regulation (BAX) and multidrug resistance (ABCG2). Different pattern of LOH has been observed between the two TGCTs groups and no common structural genetic alteration was found, suggesting of independent development for TGCT groups. LOHs of several genes with synergistic effect (CDH1, CDKN2A, RB1, TP53), as well as higher incidence of LOH in TGCTs harboring highly metastatic and chemoresistant histological components, may provide a clue to their clinical behavior. The analysis of genes involved in DNA damage repair showed no changes in agreement with the fact MSI has not been observed, and most of TGCTs respond well to therapy. Genetic background of these tumors may help to develop better patient management strategies in regard to usual invasive therapy regimes.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

POVEZANOST RADA