Naslov
Low serum MMP-1 in breast cancer : a negative prognostic factor?

Autori
Kulić, Ana ; Dedić Plavetić, Natalija ; Vrbanec, Jurica ; Sirotković-Skerlev, Maja

Izvornik
Biomarkers (1354-750X) 17 (2012), 5; 416-421

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
proteases; prognosis; clinicopathological correlation

Sažetak
In this study we investigated the prognostic significance of serum matrix metalloproteinase (MMP)-1 levels in early-stage breast cancer patients and correlated these levels with various clinicopathologic parameters. MMP-1 levels were determined by enzyme-linked immunosorbent assay. MMP-1 serum levels in patients (n = 60) were significantly lower than in healthy subjects (n = 20, p < 0.0001). We found significant negative correlation between serum levels of MMP-1 and several negative prognostic factors of breast cancer. Kaplan-Meier analysis showed significantly shorter 5-year survival in patients with lower values of MMP-1 compared to those with high levels of MMP-1 (p = 0.0147). Our results suggest a negative prognostic role of low serum MMP-1.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA