Naslov
Study of satellite DNA-mediated gene regulation in red flour beetle Tribolium castaneum (Herbst, 1797)

Autori
Akrap, Ivana

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, diplomski rad, diplomski

Fakultet
Prirodoslovno-matematički

Mjesto
Zagreb

Datum
11.02

Godina
2013

Stranica
52

Mentor
Ugarković, Đurđica

Neposredni voditelj
Feliciello, Isidoro

Ključne riječi
cis-regulatory elements; satellite polymorphism; TCAST satellite

Sažetak
Satellite DNAs are tandemly repeated sequences that constitute a considerable part of the genomic DNA of many eukaryotic organisms. They represent a major building element of pericentromeric and centromeric heterochromatin. The existence of conserved motifs and structural properties and their transcriptional activity suggest that, in addition to participating in centromere and heterochromatin formation, satellite DNAs might also act as cis-regulatory elements of gene expression. TCAST represents major satellite DNA in the red flour beetle Tribolium castaneum. Dispersed form of TCAST satellite was associated with 101 protein-coding genes. This study reveals polymorphism of dispersed TCAST satellite-like elements among strains of T. castaneum and gives a strong indication for the role of site specific recombination as a mechanism of dispersion of repetitive elements. The results of this study also suggest the role of dispersed TCAST satellite-like elements in regulation of genes located in their vicinity, under specific heat stress conditions.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA