Naslov
Low Interferon Gamma Producer Genotype And Acute Kidney Allograft Rejection

Autori
Zibar, Lada ; Barbić, Jerko ; Pasini, Josip ; Šimunović, Dalibor ; Galić, Josip

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Urology Meetings / - , 2007, 90-90

Skup
EAU 7th Central European Meeting

Mjesto i datum
Zagreb, Hrvatska, 26.10.2007. - 27.10.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
interferon gamma; genotype; kidney; rejection

Sažetak
Aim of our study was to analyze specific polymorphisms in genes for cytokines TNF-a, TGF- pi, IL-10, IL-6 and IFN-y and relation of those polymorphisms to the acute rejection in kidney transplantation. Study included 50 adult patients (21 males, 29 females) with the first cadaver kidney transplant. Specific gene polymorphism for selected cytokines (TNF-a, TGF-pl, IL-10, IL-6 and IFN-y) was determined using commercially available tray using DNA isolated from peripheral blood leukocytes by polymerase chain reaction sequence specific primers method. According to the obtained genotype patients were grouped in the certain level of cytokine production as following: for TNF-a and IL-6- low and high producers, and for TGF-pi, IL- 10 and IFN-y- high, intermediate and low producers. Data on history of acute rejection were taken from medical records and the diagnosis was made based on clinical signs or was biopsy proven. We had 19 patients with history of acute rejection. Patients with history of acute rejection did not differ significantly from those without rejection episodes in TNF-a, TGF-pi, IL10 and IL-6 genotypes. History of acute rejection differed significantly with respect to IFN-y genotype (Chi-square=10.899, p=0.004). Patients with low producer AA genotype for IFN-y (n=12) did not have acute rejection episodes. Genotype for cytokines TNF-a, TGF-pi, IL-10 and IL-6 was not associated with kidney allograft acute rejection occurrence. Low IFN-y producer genotype seems to be protective against acute rejection of kidney transplant. Knowing a role of IFN- y as a cytokine that increases MHC expression on epithelial and endothelial cells and increases the activity of natural killer cells and macrophages thus promoting alloresponse we may conclude that those with low-producing genotype for IFN-y are somewhat protected from acute rejection episodes.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA