Naslov
Trombocitni serotonin i kolesterol kod bolesnika s depresijom
(Thrombocyte serotonin and serum cholesterol in depressed patients)

Autori
Ruljancic, Nedjeljka ; Mihanovic, Mate ; Cepelak, Ivana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Biochemia Medica / AM Šimundić - Zagreb, 2012, A75-A75

Skup
2nd European Joint Congress of EFLM and UEMS

Mjesto i datum
Dubrovnik, Hrvatska, 10.10.2012. - 13.10.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
trombocitni serotonin; kolesterol; depresija
(thrombocyte serotonin; cholesterol; depression)

Sažetak
Introduction Numerous studies have confirmed the connection of reduced serum cholesterol and thrombocyte serotonin concentration with suicidal behavior in psychiatric patients. Materials and methods In accordance to ICD-10, 55 depressed patients with suicide attempt and 77 depressed patients with no suicide attempt were separated in two subgroups ; F32.2 and F33.2. Control group was presented by the healthy blood donors. The fasting serum cholesterol concentration was established using standard enzymatic method, while the thrombocyte serotonin concentration was determined by ELISA method. Results The ANOVA test (N= 228, Fratio=8.26, p<0.001) found significant difference of cholesterol concentration, with lowest concentration in the group of depressed patients with attempted suicide, diagnoses F32.2 (p=0.031) and F33.2 (p=0.011), compared to the group of depressed patients without attempted suicides. Upon gender stratification, the significance remained for the female patients (ANOVA, N=125, Fratio=6.06, p=0.003). The thrombocyte serotonin was found to be significantly different in all groups (SNK post hoc test, p<0.05, N=187, Fratio=37.69, p<0.001), with the lowest thrombocyte serotonin in the group of depressed patients with no suicide attempt (F32.2), compared to the same diagnosis with suicide attempt (MW-test, p=0.018). The same significance was found for the group of female (ANOVA, N=103, Fratio =11.81, p<0.001) and male patients (ANOVA, N=84, Fratio=30.40, p<0.001). Conclusion In the group of depressed patients with attempted suicide, lower serum cholesterol values have been confirmed. In the group of depressed patients with no suicide attempt, lower values of thrombocyte serotonin have been confirmed, presumably as the response to the psychopharmacological therapy.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

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