Naslov
Antifungal and antiochratoxigenic properties of new synthetized analogues of dehydroacetic acid

Autori
DURAKOVIĆ S., SUŠNIK I., GALIĆ J., RAJNOVIĆ P., MARKOV K., POSPIŠIL O., STILINOVIĆ L.

Izvornik
Microbiology (New York) (0026-3656) 26 (1989), 1; 1-14

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
DHA; DHT; BrDHT; Aspergillus ochraceus; ochratoxin A

Sažetak
The effect of dehydroacetic acid (DHA) and its new synthetized analogues, 4- hydroxy-3-(p- toluoyl)-6-(p-tolil)-2H-pyrane-2-one (DHT) and 5-bromo-4-hydroxy-3-(p- toluoyl)-6-(p-tolil)-2H- pyrane-2-one (BrDHT) on growth and ochratoxin A accumulation by Aspergillus ochraceus NRRL 3174 was studied in yeast-extract-sucrose (YES) medium to determine the possible use of these compounds as a means of controlling ochratoxin A accumulation. Experiments were carried out in a stationary culture at temperatures of 15 oC and 25 oC, respectively during 20 days. Mycelial dry weights were determined gravimetrically, and concentration of ochratoxin A was quantitated fluorodensitometrically using a Camag TLC Scanner. Concentrations of DHA and DHT of 0, 1 and 0, 2 mmol x times x L-1 respectively stimulated, but concentrations higher than 0, 5 mmol x times x L-1 of these compounds, mould growth and ochratoxin A synthesis partially inhibited.In experiments with 0, 2 mmol x times x L-1 of BrDHT mould growth and synthesis of ochratoxin A were inhibited completely depending on time and temperature of cultivation.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

POVEZANOST RADA