Naslov
BMP-6 restores bone in osteoporotic aged rats and, unlike estradiol and PTH, restores trabecular bone in ovariectomized BMP-6 knockout mice.

Autori
Šimić, Petra ; Buljan Culej, Jasminka ; Orlić, Iva ; Borovečki, Fran ; Vukičević, Slobodan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 27th Annual Meeting of the American Society for Bone and Mineral Research: Journal Of Bone And Mineral Research, 20 (Suppl 1), pp. S2-440 / - , 2005

Skup
ASBMR 27th Annual Meeting

Mjesto i datum
Nashville (TN), Sjedinjene Američke Države, 23.09.2005. - 27.09.2005

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
BMP-6; aged OVX rats;; alkaline phosphatase; collagen type I

Sažetak
BMP-6 applied systemically to aged OVX rats significantly increased bone volume and mechanical characteristics of both the trabecular and cortical bone, the osteoblast surface, serum osteocalcin and osteoprotegerin levels, and decreased the osteoclast surface, serum C-telopeptide, and interleukin-6. E2 was significantly less effective, and was not synergistic with BMP-6. Animals that discontinued BMP-6 therapy maintained bone mineral density gains for another 12 weeks. BMP-6 increased in vivo the bone expression of Acvr-1, Bmpr1b, Smad5, alkaline phosphatase, and collagen type I and decreased expression of Bmp3 and BMP antagonists, chordin and cerberus. These results show, for the first time, that systemically administered BMP-6 restores the bone inductive capacity, microarchitecture, and quality of the skeleton in osteoporotic rats.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA