Pregled bibliografske jedinice broj: 615902
Manipulation of NKG2D ligands by cytomegaloviruses : impact on innate and adaptive immune response
Manipulation of NKG2D ligands by cytomegaloviruses : impact on innate and adaptive immune response // Frontiers in Immunology, 2 (2011), 85, 11 doi:10.3389/fimmu.2011.00085 (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 615902 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Manipulation of NKG2D ligands by cytomegaloviruses :
impact on innate and adaptive immune response
Autori
Slavuljica, Irena ; Krmpotić, Astrid ; Jonjić, Stipan
Izvornik
Frontiers in Immunology (1664-3224) 2
(2011);
85, 11
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
NKG2D ; cytomegalovirus ; immune evasion
Sažetak
NKG2D is a potent activating receptor expressed on NK cells, NKT cells, γδ T cells, and CD8 T cells. NKG2D recognizes cell surface molecules structurally related to MHC class I proteins induced by infection or other type of cellular stress. The engagement of NKG2D leads to NK cell cytotoxicity and cytokine secretion or to a co- stimulation of CD8 T cells. Both human and mouse cytomegalovirus (CMV) have evolved numerous mechanisms to evade NKG2D-mediated immune response. This review describes the mechanisms used by CMV to inhibit NKG2D ligand expression and the recent advances in exploiting the NKG2D recognition pathway for mounting efficient and long-lasting immune response.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
MZOS-062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Jonjić, Stipan, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
