Naslov
BMP-6 increases bone mineral density and reduces glycemia in osteopenic mice

Autori
Šimić, Petra ; Buljan Culej, Jasminka ; Orlić, Iva ; Žuvić, Marijan ; Borovečki Fran ; Vukičević, Slobodan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 33rd European Symposium on Calcified Tissues ; u: Calcified Tissue International 78 (2006) (S1) S17-S167 / Civitelli, Roberto ; Ralston, Stuart H. - : Springer, 2006, 123-123

Skup
33rd European Symposium on Calcified Tissues

Mjesto i datum
Prag, Češka Republika, 10.05.2006. - 14.05.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
BMP-6; bone density; glycemia in osteopaenic mice

Sažetak
Despite the variety of drugs for treating osteoporosis and diabetes, there is a great need for developing new anabolic therapy for patients with severe bone loss and diabetic drugs with a prolonged therapeutic interval. BMP-6 knock-out (Bmp-6 -/-) mice have reduced trabecular bone volume of the peripheral skeleton, under developed pancreas and a reduction in the size of stomach and spleen, causing fusion of the liver and duodenum. Immunohistochemically we found a reduced number of Langerhans islands in the pancreas of Bmp-6 -/- mice which resulted in increased levels of the blood glucose. We suggest that BMP-6 has a strong anabolic effect on bone and, via an insulin independent pathway, reduces glycemia in rodent models of diabetes and bone loss.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
DOI: 10.1007/s00223-006-6003-y

POVEZANOST RADA