Naslov
ACCURACY OF CULTURE, RAPID UREASE TEST, HISTOLOGY, AND SEROLOGY FOR DETECTION OF HELICOBACTER PYLORI INFECTION

Autori
Katičić, Miroslava ; Presečki, Vladimir ; Dominis, Mara ; Kalenić, Smilja ; Čulig, Josip ; Prskalo, Marija ; Tićak, Mirjana ; Pavić-Sladoljev, Dubravka ; Džebro, Sonja ; Plečko, Vanda ; Strugar, Jadranka ; Boloban-Sinčić, Mirjana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
2th International Workshop on Helicobacter pylori and extragastric pathologies associated with Helicobacter pylori infection / - Rim, 1998

Skup
2th International Workshop on Helicobacter pylori and extragastric pathologies associated with Helicobacter pylori infection

Mjesto i datum
Rim, Italija, 02.06.1998. - 03.06.1998

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Helicobacter pylori; Diagnosis; Diagnostic tests

Sažetak
Aims: To compare the sensitivity (SE), specificity (SP), positive (PPV) and negative (NPV) predictive value of the most widely available invasive and noninvasive tests for diagnosis of H. pylori. Material and methods: CLO test (1 antral biopsy specimen), histology (2 corpus, 2 antral), culture (1 corpus, 1 antral) and serology (CF and ELISA) were used to assess H. pylori status in 1128 untreated patients underwent endoscopy (mean age 51, 6 ą 14, 8 ; 698 male and 430 female ; 897 peptic ulcers and 231 nonulcer dyspepsia). The “gold standard” was defined by the positive results of any two of biopsy based methods. Results: H. pylori was detected by “gold standard” in 906 (80, 3%) patients. Results are displayed in Table below: Parameter SE (%) SP (%) PPV (%) NPV (%) Invasive Culture 88, 4 88, 8 97, 0 65, 4 CLO 93, 0 89, 7 97, 3 76, 0 Histology 98, 2 83, 0 95, 9 92, 0 Noninvasive CF 91, 8 55, 2 93, 2 50, 3 ELISA 96, 3 38, 1 90, 4 63, 2 . Conclusion: The results suggest that histology was the most sensitive test for detecting H. pylori, with good positive and the best negative predictive value. Both serologic methods had the lowest combination of specificity and predictive negative value due to a great number of false-positives, suggesting posibility of H. pylori natural clearance in some patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA