Naslov
Simulation studies of multiple dipole neuromagnetic source localization : Model order and limits of source resolution
(Simulation studies of multiple dipole neuromagnetic source localization : Model order and limits of source resolution)

Autori
Supek, Selma ; Aine, Cheryl J.

Izvornik
IEEE transactions on biomedical engineering (0018-9294) 40 (1993), 6; 529-540

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
magnetoencefalography ; spatio-temporal resolution ; model order ; statistical measures of goodness-of-fit ; limits in source resolution

Sažetak
Numerical simulation studies were performed using a multiple dipole source model and a spherical approximation of the head to examine how the resolution of simultaneously active neuromagnetic sources depends upon: 1) source modeling assumptions (i.e., number of assumed dipoles) ; 2) actual source parameters (e.g., location, orientation, and moment) ; and 3) measurement errors. Forward calculations were conducted for a series of source configurations in which the number of dipoles, specific dipole parameters, and noise levels were systematically varied. Simulated noisy field distributions were fit by multiple dipole models of increasing model order (1, 2, ..., 6 and alternative statistical approaches (i.e., percent of variance, reduced chi-square, and F-ratio) were compared for their effectiveness in determining adequate model order. Limits of spatial resolution were established for a variety of multi- source configurations and noise conditions. Implications for the analysis of empirical data are discussed.

Izvorni jezik
Engleski

Znanstvena područja
Fizika

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