Naslov
Drug induced reactions to aspirin and nonsteroidal anti-inflammatory drugs
(DDrug induced reactions to aspirin and nonsteroidal anti-inflammatory drugs)

Autori
Paštar, Zrinjka ; Štajminger, Gordana ; Lipozenčić, Jasna

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Update in Dermatologic Drug Therapy

Urednik/ci
Lipozenčić, Jasna

Izdavač
Laser Plus

Grad
Zagreb

Godina
2012

Raspon stranica
415-434

ISBN
978-953-6868-39-1

Ključne riječi
aspirin (ASA) ; nonsteroidal anti-inflammatory drugs (NSAIDs) hypersensitivity ; pathomechanism ; prevention

Sažetak
Aspirin (ASA) and nonsteroidal anti- inflammatory drugs (NSAIDs) hypersensitivity is presented by urticaria, angioedema, asthma, rhinosinusitis, anaphylaxis, and with a variety of late cutaneous and organ-specific reactions. The pathomechanisms include the inhibition of cycloxygenase-1 that leads to shunting of arachidonic acid metabolism towards the 5- lipoxygenase pathway, which results in increased levels of cysteinyl leukotrienes in cross-reactive patients, and formation of specific immunoglobulin E antibodies to ASA or a single NSAID. There also are type IV hypersensitivity reactions. The diagnosis includes understanding of the pathomechanism and is necessary for prevention and management.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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