Naslov
Successful Use of Recombinant Factor VIIa in Traumatic Liver Injury : A Case Report

Autori
Baranović, Senka ; Lubina, Ivan Zvonimir ; Nikolić, Tatjana ; Maldini, Branka

Izvornik
Collegium antropologicum (0350-6134) 35 (2011), 1; 193-196

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, prethodno priopćenje, stručni

Ključne riječi
recombinant FVIIa; polytrauma; liver; coagulopathy; hemorrhage; hemostasis

Sažetak
The paper describe the use of rFVIIa in the management of massive bleeding in a patient with polytrauma involving liver injury. An 18-year-old girl with severe polytrauma sustained during a bus–car collision. She had multiple musculoskeletal injuries, severe concussion of the liver with amputation of the left liver lobe, disruption of the left hepatic vein from the inferior vena cava, and impaired hemostasis. Acute bleeding (>5 L) was not improved by conservative methods and a single dose of rFVIIa 90
g/kg was administered. Infusion of rFVIIa resulted in an immediate clinical effect with rapid improvements in blood laboratory measurements and coagulation parameters. rFVIIa should be considered as an adjunctive treatment for the control of hemorrhage in severely injured patients with uncontrolled bleeding and impaired hemostasis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA