Naslov
Helicobacter pylori and gastric malignancies

Autori
Katičić, Miroslava

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, cjeloviti rad (in extenso), pregledni

Izvornik
VI Macedonian congress of gastroenterology and hepatology Zbornik radova / Vasilevski, D. - Ohrid : Macedonian society of gastroenterology and hepatology, 2000, 15-19

Skup
VI Macedonian congress of gastroenterology and hepatology

Mjesto i datum
Ohrid, Sjeverna Makedonija, 21.09.2000. - 23.09.2000

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Helicobacter pylori; gastritis; gastric cancer; lymphoma; MALT

Sažetak
Abstract: The association between Helicobacter pylori (H. pylori) infection and gastric malignancies, cancer and MALT lymphoma, has been suggested through several lines of evidence during the last decade. Although unresolved issues still cast doubts on the real weight of these association, in the sequence of events that leads to gastric cancer or lymphoma, H. pylori appears to play a prominent role in the very initial steps as causative agent of chronic gastritis. The subsequent events in the sequence - atrophy, intestinal metaplasia, dysplasia and cancer are multifactorial involving environmental agents, host response and characteristics of the bacterial strain itself. Recognition of the causal role of H. pylori infection in the cancer induction theoretically presents tools for its prevention. The ongoing studies will show in the future whether eradication or prevention of infection are followed by a reduction in risk of cancer. Lymphomas arising from gastric mucosa-associated lymphoid tissue (MALT) may be a clonal evolution starting from the infection. In low-grade gastric MALT lymphoma cure of the infection induces complete remission in the majority of patients. Longer follow-up investigations are necessary to determine if remissions indicate a cure from the disease.

Izvorni jezik
Hrvatski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA