Naslov
Biochemomechanics of Intraluminal Thrombus in Abdominal Aortic Aneurysms

Autori
Wilson, John S. ; Virag, Lana ; DiAchille, Paolo ; Karšaj, Igor ; Humphrey, Jay D.

Izvornik
Journal of biomechanical engineering-transactions of the ASME (0148-0731) 135 (2013), 2; 021011-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
aorta; hemodynamics; stress analysis; biomechanics; inflammation; proteases; growth and remodeling

Sažetak
Most computational models of abdominal aortic aneurysms address either the hemodynamics within the lesion or the mechanics of the wall. More recently, however, some models have appropriately begun to account for the evolving mechanics of the wall in response to the changing hemodynamic loads. Collectively, this large body of work has provided tremendous insight into this life-threatening condition and has provided important guidance for current research. Nevertheless, there has yet to be a comprehensive model that addresses the mechanobiology, biochemistry, and biomechanics of thrombus-laden abdominal aortic aneurysms. That is, there is a pressing need to include effects of the hemodynamics on both the development of the nearly ubiquitous intraluminal thrombus and the evolving mechanics of the wall, which depends in part on biochemical effects of the adjacent thrombus. Indeed, there is increasing evidence that intraluminal thrombus in abdominal aortic aneurysms is biologically active and should not be treated as homogenous inert material. In this paper, we bring together diverse findings from the literature to encourage next generation models that account for the biochemomechanics of growth and remodeling in patient-specific, thrombus-laden abdominal aortic aneurysms.

Izvorni jezik
Engleski

Znanstvena područja
Strojarstvo

POVEZANOST RADA