Naslov
Concomitant polymorphism in the pseudo-peptide Me2N-pC6H4C(O)-Phe-OEt

Autori
Užarević, Krunoslav ; Kokan, Zoran ; Perić, Berislav ; Bregović, Nikola ; Kirin, Srećko I.

Izvornik
Journal of molecular structure (0022-2860) 1031 (2013); 160-167

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
pseudo-peptide ; phenylalanine ; polymorphism ; crystal structure ; solid-state transformations ; mechanochemistry

Sažetak
Pseudo-peptide Me2N-pC6H4C(O)-Phe-OEt (1) exhibits two polymorphic forms which crystallizes in non-centrosymmetric space groups, monoclinic 1m (P21) and orthorhombic 1o (P212121). Both forms occur concomitantly or as a pure phase depending on the solvent of crystallization. Single crystal X-ray diffraction revealed equivalent two-dimensional layers in both 1m and 1o, the different modes of layer stacking are caused by Csingle bondH⋯π interactions specific for each polymorph. Both solid forms are transparent in visible spectral region, with different absorbance patterns in lower UV region. Thermodynamic relations between two polymorphs were unambiguously established using room-temperature competitive slurry experiments, mechanochemistry and heating.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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