Naslov
The effect of pentadecapeptide BPC 157 on malondialdehyde levels in brain and fine motorics impairment in rat model of haloperidol and methamphetamine induced neurotoxicity

Autori
Šuran, Jelena ; Prišć, Martina ; Beluškov, Ivan ; Sikirić, Predrag ; Božić, Frane ; Sakar, Darko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Veterinary Pharmacology and Therapeutics, Volume 35, Suppl.3. / Riviere, Jim E. ; Fink-Gremmels, J. - : Wiley-Blackwell, 2012, 156-157

Skup
12th International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT 2012)

Mjesto i datum
Noordwijkerhout, Nizozemska, 08.07.2012. - 12.07.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
BPC 157; methamphetamine; malondialdehyde

Sažetak
Stabile gastric pentadecapeptide BPC 157, Gly–Glu– Pro–Pro–Pro–Gly–Lys–Pro–Ala–Asp–Asp–Ala–Gly–Leu– Val, MW 1419, has a variety of protective effects in different organs, as well as nervous system. It antagonizes haloperidol-induced behavioural supersensitivity to amphetamine which, results in dopaminergic neurotoxicity and nigrostriatum damage due to increased lipid peroxidation. Currently, BPC 157 neuroprotective effects are evaluted in a model of haloperidol- and methamphetamine-induced neurotoxicity. These models result in impaired motoric function and increased lipid peroxidation in different brain regions. The purpose of this research was to asses BPC 157 protective effects on nigrostriatum in rat model of haloperidol and methamphetamine induced neurotoxicity using fine motoric in rats as indicator of nigrostriatum function and malondialdehyde (MDA) levels as lipid peroxidation marker.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA