Naslov
The role of perforin mediated cytotoxicity in Infections

Autori
Rukavina, Daniel ; Balen-Marunić, Sanja ; Prpić, Larisa

Izvornik
Medicinski razgledi (0025-8121) 39 (2000), S4; 95-100

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Perforin; Infections; Lymphocyte mediated cytotoxicity; Hepatitis B

Sažetak
Lymphocyte dependent cytotoxicity plays an important role in protection against viral infections, infections with some intracellular parasites and in the immunological control of tumor growth (immune surveillance). Experiments with perforin knockout mice, and clinical investigations clearly showed that at the molecular level lymphocyte dependent cytotoxicity is mediated either by nonsecretory mechanisms (Fas/Fas L, TNF, TRAIL and TWEAK) or secretory mechanisms (Perforin granzymes - serine esterases). Perforin and granzymes are located in the granules of cytotoxic cells and are released in the contact area between effector and target cell. Perforin perforates target membranes forming pores which serves as conduits for apoptotic action of serine esterases. CTL and NK cells are lymphoid cells able to exert contact-dependent cytotoxicity, and they are both endowed with strong cytolytic potential. Perforin mediated cytotoxicity is of crucial importance for our protection against some viruses (noncytopathic), and partly responsible for the control of other viral and intracellular parasites infection. Perforin mediated cytotoxicity has also important role in the immune surveillance against tumor growth.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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