Naslov
Serum pneumoproteins as biomarkers of interstitial lung disease

Autori
Šegulja, Dragana ; Peroš-Golubičić, Tatjana

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, pregledni

Knjiga
Lung in non-pulmonary and systemic disease

Urednik/ci
Peroš-Golubičić, Tatjana

Izdavač
Medicinska naklada

Grad
Zagreb

Godina
2013

Raspon stranica
257-260

ISBN
978-953-176-577-0

Ključne riječi
Serum pneumoproteins ; interstitial lung disease

Sažetak
Interstitial lung diseases (ILD) include a variety of pulmonary diseases characterized by a diffuse interstitial shadows on the chest rentgenogram and a histological evidence of fibrosing alveolitis. Type II pneumocytes are the cuboidal, alveolar epithelial cells responsible for producing and secreting surfactant and most of the surfactant- associated proteins (SP-A, SP-B, SP-C, SP-D) into the alveolar lining fluid. SP-A and SP-D are hydrophilic glycoproteins whereas SP-B and SP-C are very hydrophobic proteins. Recent reports suggest that the serum markers Krebs von den Lunge-6 (KL- 6), monocyte chemoatractant protein-1 (MCP-1) and surfactant proteins A and D may be useful as diagnostic tools. KL-6 is a high-molecular-weight glycoprotein classified in humans as MUC1 mucin. KL-6 appears to be a useful marker of idiopathic pulmonary fibrosis, hypersenitivity pneumonitis, pulmonary sarcoidosis and drug- induced pneumonitis. Further, MCP-1 is a part of the C-C chemokine subfamily and has monocyte chemotactic activity. This protein also works as a chemoattractant for fibroblasts. Finally, SP-A and SP-D belong to the collectin subgroup of the C-type lectin superfamily. Their function is to reduce the surface tension at the air-liquid interface and thereby prevent alveolar collapse and atelectasis. Takahashi and coworkers conducted many studies to determine the utility of all these pneumoproteins as markers of pulmonary disease severity. They reported that the elevated SP-D level could be closely associated with alveolitis but not fibrosis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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