Naslov
Correlation of cytology, histology and immunohistochemical staining of p16 and pRb in cervical lesions

Autori
Belci, Dragan ; Sabol, Ivan ; Peteh Labinac, Loredana ; Badoual, Cécile ; Grce, Magdalena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Program/Programme & Kniga sašetaka/Abstract book 2. hrvatski kongres ginekološke onkologije s međunarodnim sudjelovanjem / 2nd Croatian Congress of Gynecological Oncology with International Participation / Kukura, Vlastimir - Zagreb : Hrvatsko ginekološko onkološko društvo, 2012, 24-25

Skup
2. hrvatski kongres ginekološke onkologije s međunarodnim sudjelovanjem / 2nd Croatian Congress of Gynecological Oncology with International Participation

Mjesto i datum
Zagreb, Hrvatska, 15.11.2012. - 17.11.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
HPV; cervical lesion; p16; pRb

Sažetak
Management of cervical lesions depends of accurate cytological diagnosis followed by histological diagnosis of punch biopsy. In addition, to those classical approaches new biomarkers seems to be promising in additional confirmation of cytological and histological diagnosis. In this study, we intended to evaluate the correlation between cytology and histology as well as p16 and pRb immunohistochemical staining in 50 cervical specimens, mostly cervical intraepithelial nepolasia (CIN) grade 1 to 3. There was statistically significant but low correlation (Spearman's correlation = 0.345, P=0.0164) between biopsy and cytology that is expected given the low sensitivity of cytology in general. After cervical treatment the cytology was mostly normal (Spearman's correlation = 0.375, P= P=0.0448) as expected. Although there is a concomitant increasing p16 staining and decreasing pRb staining with the severity of the cytological or histological diagnosis, it was not statistically significant. The p16 staining was only statistically significantly (Spearman's correlation = 0.673, P<0.0001) indication of increasing hitological grade of biopsy.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
Organizatori skupa: Hrvatsko ginekološko onkološko društvo (HGOD) & European Society of Gynaecological Oncology (ESGO)

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