Naslov
ANTIMICROBIAL RESISTANCE PATTERNS OF MICROORGANISMS FREQUENTLY ISOLATED FROM LOWER RESPIRATORY TRACT IN ICU PATIENTS

Autori
Santini, Marija ; Ladan, Vesna ; Baršić, Bruno

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Lower respiratory tract infections: problems in diagnosis and treatment / - Zagreb, 2000

Skup
European Society of Clinical Microbiology and Infectious Diseases 10th postgraduate education course

Mjesto i datum
Dubrovnik, Hrvatska, 27.09.2000. - 01.10.2000

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
resistance patterns; lower respiratory tract; intensive care unit patients

Sažetak
The aim of this study is to identify possible changes in antimicrobial resistance patterns of microorganisams most frequently isolated from lower respiratory tract in intensive care unit patients without regard to their clinical relevance. It is a prospective observational study involving two periods (from 1990 to 1995 and from 1998 to 2000), situated at the six-bed intensive care unit of the University Hospital for Infectious Diseases in Zagreb. The study involved 622 patients in the first period and 358 in the second. All patients stayed in intensive care unit for more than 48 hours. Gram-negative bacteria are still predominant isolates, representing 67% in second phase and 78.7% in first phase. The study has revealed emergance of ESBL positive strains of K. pneumoniae representing 37.5% of K. pneumoniae isolates and Stenotrophomonas maltophylia coming to the fifth place among most frequently isolated microorganisams. Changes in antimicrobial resistance patterns for three major gram-negative pathogenes were notified. Rate of resistance of K. pneumoniae to gentamicin decreased from 71.9% to 43.8%, resistance to netilmicin, amikacin and ciprofloxacin from respectively 25.8%, 46.1% and 16.9 to 0. Rate of resistance of P. aeruginosa to gentamicin increased from 57.6% to 75.0% and to netilmicin from 50.3% to 73.4% while susceptibility to amikacin did not change. There is lower rate of resistance of A. baumannii to amikacin decreasing from 78.2% to 43.8%, and no resistance to imipenem in second phase while 1.4% in the first phase.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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