Naslov
Burden and prevention of HPV related diseases: Situation in Croatia

Autori
Grce, Magdalena ; Sabol, Ivan ; Milutin Gašperov, Nina

Izvornik
Periodicum biologorum (0031-5362) 114 (2012), 2; 175-186

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
cervical cancer ; vulvar cancer ; anal cancer ; penile cancer ; oropharyngeal cancer ; genital warts ; laryngeal papillomatosis ; human papillomavirus ; HPV ; screening ; vaccination ; Croatia

Sažetak
The role of persistent infection of high-risk human papillomaviruses (HR-HPV) in cervical cancer has become convincingly established. Other anogenital cancers in women and men are also caused, to a lesser extent, by HR-HPV. In addition, most of the benign anogenital warts and laryngeal papillomatosis are caused by low-risk (LR) HPV types. All these HPV-associated diseases represent high public health burden worldwide, cervical cancer being the leading one. Nowadays, several opportunities are available to prevent cervical cancer and other HPV-related diseases. The most promising cancer preventing intervention is the HPV vaccination against the most common HPV types (16 and 18). However, secondary prevention like education and early detection of the disease by screening have demonstrated in the past great efficacy and should be continued and improved by novel prognostic methods (HPV testing and other biomarkers) in countries where it is already in place and implement in those countries that are lacking cancer control programmes. Herein, the current knowledge on HPVs, HPV-related diseases and their preventive approaches are discussed. In addition, the situation in Croatia is presented.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA