Naslov
Proteomic profiling of intestinal proteins in TFF2 mice

Autori
Vučinić, Srđan ; Horvatić, Anita ; Bujak, Maro ; Mišković, Katarina ; Cindrić, Mario ; Baus Lončar, Mirela

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Periodicum Biologorum / Periodicum Biologorum, Hrvatsko prirodoslovno društvo - Zagreb, 2012

Skup
HDIR-2 "From Bench to Clinic" Second Meeting of the Croatian Association for Cancer Research with International Participation

Mjesto i datum
Zagreb, Hrvatska, 08.11.2012. - 09.11.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
TFF2; 2-DE; proteomics

Sažetak
Trefoil factor family (TFFs) comprises three small proteins (TFF1, TFF2 and TFF3) predominantly found in mucous epithelia of gastric system but they also found in epithelia of different organs like respiratory tract, uterus, conjunctiva, thyroid gland etc. TFFs play multifunctional role in protection of mucosa through participation in apoptosis, cell migration and immune response. Expression of Tffs is deregulated in different tumors. Biological effect of proteins is best evaluated in mouse knock out models that are deficient in a specific protein. To assess the role of Tff2 protein in intestine we have compared global protein status of Tff2 knock-out mice versus wild type mice by means of two-dimensional gel electrophoresis.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA