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Pregled bibliografske jedinice broj: 604788

5-HT2A receptor antagonist M100907 reduces serotonin synthesis : an autoradiographic study

Hasegawa, Shu; Fikre-Merid, Maraki; Dikšić, Mirko
5-HT2A receptor antagonist M100907 reduces serotonin synthesis : an autoradiographic study // Brain research bulletin, 87 (2012), 1; 44-49 doi:10.1016/j.brainresbull.2011.10.009 (međunarodna recenzija, članak, znanstveni)

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Naslov
5-HT2A receptor antagonist M100907 reduces serotonin synthesis : an autoradiographic study

Autori
Hasegawa, Shu ; Fikre-Merid, Maraki ; Dikšić, Mirko

Izvornik
Brain research bulletin (0361-9230) 87 (2012), 1; 44-49

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
α-[14C]methyl-l-tryptophan; serotonin synthesis rate; 5-HT2A receptor antagonist; M100907; autoradiography

Sažetak
The effects of the administration of the serotonin (5-HT)(2A) antagonist, M100907, on 5-HT synthesis rates, were evaluated using the α-[(14)C]methyl-l-tryptophan (α-MTrp) autoradiographic method. In the treatment study, M100907 (10mg/kg) was injected intraperitoneally 30 min before the α-MTrp injection (30 μCi over 2 min). A single dose of M100907 caused a significant decrease in the synthesis in the anterior olfactory nucleus, accumbens nucleus, frontal cortex, sensory-motor cortex, cingulate cortex, medial caudate-putamen, dorsal thalamus, substantia nigra, inferior collicus, raphe magnus nucleus, superior olive, and raphe pallidus nucleus. These data suggest that the terminal 5-HT(2A) receptors are involved in the regulation of 5-HT synthesis in the entire brain. Further, 5-HT synthesis is likely regulated by the 5-HT(2A) antagonistic property of M100907 in the cortices, anterior olfactory nucleus, caudate putamen, and nucleus accumbens.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
219-1081870-2032 - Serotoninski receptori te promjena antidepresivima u štakorskom modelu depresije (Dikšić, Mirko, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Osijek

Profili:

Avatar Url Mirko Dikšić (autor)

Poveznice na cjeloviti tekst rada:

doi dx.doi.org www.sciencedirect.com

Citiraj ovu publikaciju:

Hasegawa, Shu; Fikre-Merid, Maraki; Dikšić, Mirko
5-HT2A receptor antagonist M100907 reduces serotonin synthesis : an autoradiographic study // Brain research bulletin, 87 (2012), 1; 44-49 doi:10.1016/j.brainresbull.2011.10.009 (međunarodna recenzija, članak, znanstveni)
Hasegawa, S., Fikre-Merid, M. & Dikšić, M. (2012) 5-HT2A receptor antagonist M100907 reduces serotonin synthesis : an autoradiographic study. Brain research bulletin, 87 (1), 44-49 doi:10.1016/j.brainresbull.2011.10.009.
@article{article, author = {Hasegawa, Shu and Fikre-Merid, Maraki and Dik\v{s}i\'{c}, Mirko}, year = {2012}, pages = {44-49}, DOI = {10.1016/j.brainresbull.2011.10.009}, keywords = {α-[14C]methyl-l-tryptophan, serotonin synthesis rate, 5-HT2A receptor antagonist, M100907, autoradiography}, journal = {Brain research bulletin}, doi = {10.1016/j.brainresbull.2011.10.009}, volume = {87}, number = {1}, issn = {0361-9230}, title = {5-HT2A receptor antagonist M100907 reduces serotonin synthesis : an autoradiographic study}, keyword = {α-[14C]methyl-l-tryptophan, serotonin synthesis rate, 5-HT2A receptor antagonist, M100907, autoradiography} }
@article{article, author = {Hasegawa, Shu and Fikre-Merid, Maraki and Dik\v{s}i\'{c}, Mirko}, year = {2012}, pages = {44-49}, DOI = {10.1016/j.brainresbull.2011.10.009}, keywords = {α-[14C]methyl-l-tryptophan, serotonin synthesis rate, 5-HT2A receptor antagonist, M100907, autoradiography}, journal = {Brain research bulletin}, doi = {10.1016/j.brainresbull.2011.10.009}, volume = {87}, number = {1}, issn = {0361-9230}, title = {5-HT2A receptor antagonist M100907 reduces serotonin synthesis : an autoradiographic study}, keyword = {α-[14C]methyl-l-tryptophan, serotonin synthesis rate, 5-HT2A receptor antagonist, M100907, autoradiography} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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