Naslov
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Autori
Manning, A.K. ; ... ; Boban, Mladen ; ... ; Budimir, Danijela ; ... ; Kolčić, Ivana ; ... ; ... ; Pehlić, Marina ; ... ; Peričić, Marijana ; ... ; Polašek, Ozren ; ... ; Rudan, Igor ; Zelenika, Diana ; Zemunik, Tatijana ; Zgaga, Lina ; ... ; Langenberg C.

Izvornik
Nature genetics (1061-4036) 44 (2012); 659-669

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
loci; SNP; insulin

Sažetak
Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways might be uncovered by accounting for differences in body mass index (BMI) and potential interactions between BMI and genetic variants. We applied a joint meta-analysis approach to test associations with fasting insulin and glucose on a genome-wide scale. We present six previously unknown loci associated with fasting insulin at P < 5 × 10(-8) in combined discovery and follow-up analyses of 52 studies comprising up to 96, 496 non-diabetic individuals. Risk variants were associated with higher triglyceride and lower high-density lipoprotein (HDL) cholesterol levels, suggesting a role for these loci in insulin resistance pathways. The discovery of these loci will aid further characterization of the role of insulin resistance in T2D pathophysiology

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti

Napomena
Consortium DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) ; The Multiple Tissue Human Expression Resource (MUTHER) Consortium.

POVEZANOST RADA