Naslov
Efficacy of RG3-Enriched Korean Red ginseng (steamed Panax Ginseng C.A. Meyer) extract on arterial stiffness and blood pressure in healthy volunteers

Autori
Rahelić, Dario ; Božikov, Velimir ; Jovanovski, Elena ; Jenkins, Alexandra ; Sung, M.-K. ; Mucalo, Iva ; Romić, Željko ; Vuksan, Vladimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
30th International Symposium on diabetes and Nutrition Book of proceedings / - , 2012, 24-24

Skup
30th International Symposium on diabetes and Nutrition

Mjesto i datum
Atena, Grčka, 28.06.2012. - 01.07.2012

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Korean red ginseg; arterial stiffness; augmentation index; blood pressure

Sažetak
Background: Aortic augmentation index (AIx) and central and peripheral blood pressures (BP) are validated predictors of vascular health and cardiovascular disease (CVD) morbidity and mortality. Korean Red ginseng, and specifically, its RG3 ginsenoside component have been implicated as vasodilators with positive effects on vascular parameters, and thus warrant further investigation in humans as potential treatments for reducing the aforementioned cardiovascular disease risk factors. Objectives: The present study sought to acutely evaluate the efficacy of 10%Rg3-enriched Korean red ginseng (KRG) on arterial stiffness and peripheral and central blood pressure in healthy adult volunteers. Design: Double-blind, randomized, placebo-controlled, cross-over. Methods: After a 10-12h overnight fast, 17 healthy individuals (6M:11F ; age 25±3 ; BMI 22±0, 8 ; SBP 111±4 ; DBP 69±2 mmHg) were randomly assigned to receive either 400mg 10% Rg3-enriched Korean Red Ginseng extract or 400 mg corn-starch placebo. AIx and central (aortic) BP were evaluated using applanation tonometry by radial pulse wave analysis. peripheral (brachial) BP was evaluated oscillometrically. Measurements were taken at baseline, after which treatment was administered, and again at one-hour intervals post-treatment for 3 hours. A standardized meal was administered after two hours. Results: Compared with placebo, there was a significant reduction in peripheral mean arterial pressure (p=0, 046), peripheral diastolic BP (p=0, 015), and central systolic BP (p=0, 02) three hours after the administration of 10% Rg3-enriched KRG extract. Central diastolic BP and central mean arterial pressure were significantly lower at one (p=0, 035, 0, 041) and three hours post-treatment (p=0, 025, 0, 009). Though AIx and peripheral systolic BP were observed to decrease following treatment in comparison to placebo, these effects did not reach statistical significance. Conclusion: The present study is the first to demonstrate that Korean Red ginseng extract containing 10% Rg3 effectively lowers cantral and peripheral mean arterial pressures in healthy, young adults. We believe the benefits of Rg3-enriched Korean Red Ginseng extract demonstrated in the present study may be even nore pronounced in higher-risk subjects, and warrants further clinical testing. -enriched Korean Red Ginseng

Izvorni jezik
Engleski

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