Synthesis, DNA Interactions and Anticancer Evaluation of Novel Diamidine Derivatives of 3, 4-Ethylenedioxythiophene

Stolić, Ivana; Avdičević, Monika; Bregović, Nikola; Piantanida, Ivo; Glavaš-Obrovac, Ljubica; Bajić, Miroslav

doi:10.5562/cca2141

Pregled bibliografske jedinice broj: 603584

Synthesis, DNA Interactions and Anticancer Evaluation of Novel Diamidine Derivatives of 3, 4-Ethylenedioxythiophene

Stolić, Ivana; Avdičević, Monika; Bregović, Nikola; Piantanida, Ivo; Glavaš-Obrovac, Ljubica; Bajić, Miroslav

Synthesis, DNA Interactions and Anticancer Evaluation of Novel Diamidine Derivatives of 3, 4-Ethylenedioxythiophene // Croatica chemica acta, 85 (2012), 4; 457-467 doi:10.5562/cca2141 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 603584 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Synthesis, DNA Interactions and Anticancer Evaluation of Novel Diamidine Derivatives of 3, 4-Ethylenedioxythiophene

Autori
Stolić, Ivana ; Avdičević, Monika ; Bregović, Nikola ; Piantanida, Ivo ; Glavaš-Obrovac, Ljubica ; Bajić, Miroslav

Izvornik
Croatica chemica acta (0011-1643) 85 (2012), 4; 457-467

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
amide-amidines ; 3 ; 4-ethylenedioxythiophene ; diarylamidine ; DNA/RNA binding ; antitumor activity

Sažetak
Eight novel diamidino 3, 4-ethylenedioxythiophene-2, 5-dicarboxanilides (5a–h), obtained by condensation reaction of 3, 4-ethylenedioxythiophene-2, 5-dicarbonyl chloride and corresponding 3- or 4-aminobenzamidines, were evaluated for interactions with double-stranded DNA and RNA, and their cytotoxicity was assayed against the panel of human cancer cell lines. All compounds preferentially bind into the minor groove of DNA and had higher affinity for DNA than for RNA. Compounds 5a–h showed a moderate antiproliferative effect toward the panel of seven carcinoma cells line, whereby the highest inhibitory potential was displayed by compound 5a with unsubstituted amidino moieties in para position.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti

POVEZANOST RADA

Projekti:
MZOS-053-0982914-2965 - Dizajn i sinteza bisamidina sa protutumorskim djelovanjem (Bajić, Miroslav, MZOS ) ( CroRIS)
MZOS-098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Piantanida, Ivo, MZOS ) ( CroRIS)
MZOS-119-1191342-2960 - Elektroliti i koordinacijske reakcije u otopini (Tomišić, Vladislav, MZOS ) ( CroRIS)
MZOS-219-0982914-2176 - Mehanizam bioloških učinaka novih malih molekula na stanice tumora čovjeka (Glavaš Obrovac, Ljubica, MZOS ) ( CroRIS)
MZOS-219-0982914-2179 - Uloga malih zaštitinih TFF proteina u zdravlju i bolesti (Belovari, Tatjana, MZOS ) ( CroRIS)

Ustanove:
Veterinarski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
Medicinski fakultet, Osijek

Profili:

Ivo Piantanida (autor)