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Pregled bibliografske jedinice broj: 602475

Antiproliferative potency of novel benzofuran-2-carboxamides on tumor cell lines: cell death mechanisms and determination of crystal structure

Hranjec, Marijana; Sović, Irena; Ratkaj, Ivana; Pavlović, Gordana; Ilić, Nataša; Valjalo, Linda; Pavelić, Krešimir; Kraljević Pavelić, Sandra; Karminski-Zamola, Grace
Antiproliferative potency of novel benzofuran-2-carboxamides on tumor cell lines: cell death mechanisms and determination of crystal structure // European journal of medicinal chemistry, 59 (2013), 111-119 doi:10.1016/j.ejmech.2012.11.009 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 602475 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Antiproliferative potency of novel benzofuran-2-carboxamides on tumor cell lines: cell death mechanisms and determination of crystal structure

Autori
Hranjec, Marijana ; Sović, Irena ; Ratkaj, Ivana ; Pavlović, Gordana ; Ilić, Nataša ; Valjalo, Linda ; Pavelić, Krešimir ; Kraljević Pavelić, Sandra ; Karminski-Zamola, Grace

Izvornik
European journal of medicinal chemistry (0223-5234) 59 (2013); 111-119

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
benzofuranes ; carboxamides ; antiproliferative activity ; apoptosis ; crystal structure determination

Sažetak
In this manuscript the synthesis and biological activity of novel heterocyclic derivatives of benzofuran-2-carboxamides 3a-3j and 6a-6f is presented. Biological evaluation in vitro revealed that only few compounds exerted concentration-depended antiproliferative effects on tumour cell lines at micromolar concentrations. In particular, 2-imidazolynyl substituted compound 6f showed selectivity on SK-BR-3 cell line while 2-N-acetamidopyridyl substituted 3h and 2-imidazolynyl substituted amide 3i showed selective concentration-dependent antiproliferative effects on SW620 cell line. Compounds 3h and 6f induced apoptosis while compound 3i acted through a cell death mechanism other than apoptotis.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
MZOS-098-1191344-2943 - Protein-ligand međudjelovanja na atomnoj razini (Luić, Marija, MZOS ) ( CroRIS)
MZOS-125-0982464-1356 - Novi heterocikli kao antitumorski i antivirusni (pametni) lijekovi (Hranjec, Marijana, MZOS ) ( CroRIS)
MZOS-335-0000000-3532 - Uloga IGF2 i signalni putovi nizvodno u karcinomima pluća čovjeka (Peter-Katalinić, Jasna, MZOS ) ( CroRIS)
098-0982464-2393 - Molekularna obilježja miofibroblasta Dupuytrenove bolesti

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Tekstilno-tehnološki fakultet, Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Sveučilište u Rijeci - Odjel za biotehnologiju

Profili:

Avatar Url Irena Sović (autor)

Avatar Url Marijana Hranjec (autor)

Avatar Url Krešimir Pavelić (autor)

Avatar Url Gordana Pavlović (autor)

Avatar Url Sandra Kraljević Pavelić (autor)

Avatar Url Ivana Ratkaj (autor)

Avatar Url Grace Karminski-Zamola (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com dx.doi.org

Citiraj ovu publikaciju:

Hranjec, Marijana; Sović, Irena; Ratkaj, Ivana; Pavlović, Gordana; Ilić, Nataša; Valjalo, Linda; Pavelić, Krešimir; Kraljević Pavelić, Sandra; Karminski-Zamola, Grace
Antiproliferative potency of novel benzofuran-2-carboxamides on tumor cell lines: cell death mechanisms and determination of crystal structure // European journal of medicinal chemistry, 59 (2013), 111-119 doi:10.1016/j.ejmech.2012.11.009 (međunarodna recenzija, članak, znanstveni)
Hranjec, M., Sović, I., Ratkaj, I., Pavlović, G., Ilić, N., Valjalo, L., Pavelić, K., Kraljević Pavelić, S. & Karminski-Zamola, G. (2013) Antiproliferative potency of novel benzofuran-2-carboxamides on tumor cell lines: cell death mechanisms and determination of crystal structure. European journal of medicinal chemistry, 59, 111-119 doi:10.1016/j.ejmech.2012.11.009.
@article{article, author = {Hranjec, Marijana and Sovi\'{c}, Irena and Ratkaj, Ivana and Pavlovi\'{c}, Gordana and Ili\'{c}, Nata\v{s}a and Valjalo, Linda and Paveli\'{c}, Kre\v{s}imir and Kraljevi\'{c} Paveli\'{c}, Sandra and Karminski-Zamola, Grace}, year = {2013}, pages = {111-119}, DOI = {10.1016/j.ejmech.2012.11.009}, keywords = {benzofuranes, carboxamides, antiproliferative activity, apoptosis, crystal structure determination}, journal = {European journal of medicinal chemistry}, doi = {10.1016/j.ejmech.2012.11.009}, volume = {59}, issn = {0223-5234}, title = {Antiproliferative potency of novel benzofuran-2-carboxamides on tumor cell lines: cell death mechanisms and determination of crystal structure}, keyword = {benzofuranes, carboxamides, antiproliferative activity, apoptosis, crystal structure determination} }
@article{article, author = {Hranjec, Marijana and Sovi\'{c}, Irena and Ratkaj, Ivana and Pavlovi\'{c}, Gordana and Ili\'{c}, Nata\v{s}a and Valjalo, Linda and Paveli\'{c}, Kre\v{s}imir and Kraljevi\'{c} Paveli\'{c}, Sandra and Karminski-Zamola, Grace}, year = {2013}, pages = {111-119}, DOI = {10.1016/j.ejmech.2012.11.009}, keywords = {benzofuranes, carboxamides, antiproliferative activity, apoptosis, crystal structure determination}, journal = {European journal of medicinal chemistry}, doi = {10.1016/j.ejmech.2012.11.009}, volume = {59}, issn = {0223-5234}, title = {Antiproliferative potency of novel benzofuran-2-carboxamides on tumor cell lines: cell death mechanisms and determination of crystal structure}, keyword = {benzofuranes, carboxamides, antiproliferative activity, apoptosis, crystal structure determination} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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  • CA Search (Chemical Abstracts)

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