Naslov
Three-day course of Azithromycin vs. 10-day course of Amoxicillin/Clavulanate in the treatment of acute sinusitis.

Autori
Pajić-Penavić, Ivana ; Klapan, Ivica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Abstract Book. / - , 2002

Skup
19th Congress of the European Rhinologic Society

Mjesto i datum
Ulm, Njemačka, 15.06.2002. - 21.06.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Acute sinusitis; therapy

Sažetak
Purpose: We compared the efficacy and tolerability of a 3-day course of azithromycin (AZT)with a 10-day course of amoxicillin/clavulanic acid (ACA) in adults acute sinusitis. Patients and Methods: One hundred adult patients with acute sinusitis were included in an open, randomized study. Clinical diagnosis of sinusitis was confirmed by nasal endoscopy, sinus radiography, and (when possible) by culture of sinus aspirate. Patients were randomized to receive AZT (500 mg once daily for 3 days) or ACA (625 mg every 8 hours for 10 days). Results: A significantly faster resolution of signs and symptoms of sinusitis was observed in the AZT-treated patients. By the end of therapy (days 10-12), 95% of the patients in the AZT group and 74% in the ACA group were cured. The remaining patients' condition was improved. By the follow-up visit, cure was achieved in 98% of the AZT-treated patients, and 91% of the ACA-treated patients. Treatment failure was observed in three patients from the ACA group, and relapse occured in one patient from both groups. Bacteriologic eradication was achieved in 23/23 and 21/24 patients treated with AZT and ACA, respectively. Both drugs were well tolerated. Two patients (4%) from the AZT group and five patients (105) from the ACA group reported mild gastrointestinal disturbances. Conclusions: In adults with acute sinusitis, a 3-day cours of AZT was effective and well tolerated as a 10-day course of ACA. A significantly simpler dosage regimen and faster clinical effect were the advantages of AZT.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA