Naslov
Evaluating participant performance in general medical biochemistry - standardization of creatinine measurements

Autori
Perkov, Sonja ; Flegar-Meštrić, Zlata

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
2nd European Joint Congress of EFLM and UEMS «Laboratory Medicine at the Clinical Interface» and 7th Congress of the Croatian Society for Medical Biochemistry and Laboratory Medicine (CSMBLM) / Šimundić, Ana-Maria - Zagreb : Croatian Society for Medical Biochemistry and Laboratory Medicine, 2012, A27-A27

Skup
2nd European Joint Congress of EFLM and UEMS «Laboratory Medicine at the Clinical Interface» i 7th Congress of the Croatian Society for Medical Biochemistry and Laboratory Medicine (CSMBLM)

Mjesto i datum
Dubrovnik, Hrvatska, 10.10.2012. - 13.10.2012

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
standardization of creatinine measurements; national EQA program

Sažetak
The standardization of creatinine measurements are critical to promoting early detection and management of chronic kidney disease and is mandatory before the routine implementation of the estimated glomerular filtration rate in clinical practice. Actual results for serum creatinine measurement in Croatia were compared with the current recommendations based on creatinine measurements traceable to isotope dilution mass spectrometry (IDMS) reference method within the national External Quality Assessment (EQA) Scheme conducted through Croatian Centre for Quality Assessment in Laboratory Medicine (CROQALM). The results of the cycle 2/2011, 3/2011 and 1/2012 from 187 medical biochemistry laboratories were evaluated. The uncompensated kinetic Jaffe method traceable to National Institute of Standards and Technology (NIST) Standard Reference Material (SRM) 909b level 2 is most widely used in medical biochemistry laboratories (80%, 73% and 68% of participants in the survey 2/2011, 3/2011 and 1/2012, respectively). Only 17%, 24% and 29% laboratories in the survey 2/2011, 3/2011 and 1/2012 used standardized creatinine methods traceable to the IDMS method and SRM 967. The interlaboratory SD for compensated kinetic Jaffe method group, traceable to the IDMS method and SRM 967 was very high: 12, 1 µmol/L at a creatinine concentration of 98, 8 µmol/L (12%), 19, 3 µmol/L at a creatinine concentration of 204 µmol/L (9%) and 28, 6 µmol/L at a creatinine concentration of 495, 8 µmol/L (6%). One of the main goals of the Croatian EQA program in 2012 is to promote laboratories to implement standardized method and reduce the inter-laboratory variability which affects the total error for creatinine measurement.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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