Naslov
A Study of the Genetic Variability of Human Respiratory Syncytial Virus in Croatia, 2006–2008

Autori
Forčić, Dubravko ; Ivančić-Jelečki, Jelena ; Mlinarić-Galinović, Gordana ; Vojnović, Gordana ; Babić-Erceg, Andrea ; Tabain, Irena

Izvornik
Journal of medical virology (0146-6615) 84 (2012), 12; 1985-1992

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
human respiratory syncytial virus; phylogenetic analysis; genetic variability; molecular epidemiology

Sažetak
Abstract Human respiratory syncytial virus (HRSV) is a common etiological agent of acute lower respiratory tract disease in infants. The molecular epidemiology of HRSV in Croatia over four consecutive seasons (from 2006 to 2008) was investigated. A total of 72 HRSV samples were chosen from 696 screened cases in a pediatric clinic in Zagreb. Molecular characterization of HRSV revealed the predominance of HRSV group B viruses in the first two epidemic seasons and HRSV group A viruses in the next two seasons. According to the phylogenetic analysis, NA1 and BA9 were the predominant circulating HRSV genotypes detected during the study. Overall, 82.9% of all HRSV A strains belonged to the NA1 genotype. The HRSV B genotype BA9, detected in two consecutive seasons (2006 and 2007), was the predominant circulating HRSV B genotype, accounting for 80.6% of all HRSV B strains. This study provides data on the circulation pattern of HRSV genotypes in Croatia and their molecular characterization.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA