Naslov
Influence of Differentiation Grade Expressed by Gleason Score on Survival in Prostate Cancer Patients

Autori
Milostić, Kazimir ; Tomić, Snježana ; Trgo, Gorana ; Olujić, I

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Acta Clinica Croatica 41(2) / Šerić, Vesna - Zagreb : Klinički bolnički centar Sestre milosrdnice, 2002, 171-171

Skup
13th Ljudevit Jurak International Symposium on Comparative Pathology

Mjesto i datum
Zagreb, Hrvatska, 07.06.2002. - 08.06.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
prostate cancer; differentation grade

Sažetak
Through a retrospective clinical study we present the influence of differentation grade (Gleason score) on survival in patients with prostate cancer. The study included operative material of 50 prostate cancers, overall age 72.5 (51-87) years. The patients were operated on with transurethral resection (35%-70%) and classic transvesical adenomectomy (15%-30%). After histologic analysis, Gleason score was determined. The patients were classified in three groups: well (Gleason score 2, 3 and 4), moderately (Gleason score 5, 6 and 7) and poorely differentiated carcinomas (Gleason score 8, 9 and 10). Comparison of survival of patients with well and moderately differentiated carcinomas showed no statistically significant survival difference (log rank=3.41 ; p=0.065). Comparison of survival of patients with moderately and poorely differentiated carcinomas revealed no statistically significant survival difference either (log rank=2.09 ; p=0.148). However, comparing the groups with well and poorly differentiated carcinomas, a statistically significant difference (log rank=14.7 ; p=0.0001) was found. Because of that, we separated moderate group of the carcinomas with a cut off-7 and obtained high statistical significance in survival (log rank=8.73 ; p=0.031). Patients with Gleason score 2-6 had average survival of 94 months, but patients with Gleason score 7-10 had average survival of only 47 months. Univariate analysis of the differentiation grade showed the high statistical significance to be a prognostic factor in patients with prostate carcinoma. Differentiation grade is clinically useful to identify tumors with poor and good biological behavior, as well as patients in whom there is a good reason for radical surgery and adjuvant postoperative therapy.

Izvorni jezik
Engleski

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