Naslov
Optimization of matrix solid-phase dispersion for liquid chromatography tandem mass spectrometry analysis of 12 pharmaceuticals in sediments

Autori
Mutavdžić Pavlović, Dragana ; Pinušić, Tea ; Periša, Martina ; Babić, Sandra

Izvornik
Journal of Chromatography A (0021-9673) 1258 (2012); 1-15

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
pharmaceuticals ; matrix solid-phase dispersion ; liquid chromatography-tandem mass spectrometry ; sediment

Sažetak
The matrix solid-phase dispersion (MSPD) technique accompanied with LC-MS/MS detection for the purpose of determination of twelve pharmaceuticals (sulfaguanidine, sulfadiazine, sulfamethazine, sulfamethoxazole, trimethoprim, roxithromycin, praziquantel, febantel, enrofloxacin, ciprofloxacin, norfloxacin and procaine) applied to sediment samples has been described in this paper. Different parameters, such as the type of solid phase, the elution solvent and its volume have been investigated. The analytes were successfully extracted by C18 as an MSPD sorbent with 5 mL of acetonitrile: 5% of oxalic acid = 6:4 (v/v) as an elution solvent. The proposed method provides a linear response over the concentration range of 0.0005-100 µg/g, depending on pharmaceuticals with correlation coefficients above 0.9928 in all cases except for trimethoprim (0.988976). Also, the method has revealed low limits of detection (0.125-500 ng/g), good precision (withinintra and inter-- and between- day), a relative standard deviation below 15% and recoveries above 80%, except for procaine, roxithromycin, febantel and enrofloxacin. The method has been successfully applied to analysis of different sediment samples.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA