Naslov
Influence of immunosuppressive regimen change on renal function in liver transplant recipiens

Autori
Ožvald, I ; Mrzljak, A ; Radišić Biljak, V ; Perkov, S ; Flegar- Meštrić, Z.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Biochemia Medica 2012 ; 22(3):267-402 ; A17-A204 / Šimundić, AM - Zagreb : Hrvatsko društvo za medicinsku biokemiju i laboratorijsku medicinu (HDMBLM), 2012, A196-A196

Skup
2nd European Joint Congress of European Federation of Clinical Chemistry and Laboratory Medicine /EFCC) and European Union of Medical Specialists (UEMS)/ 7th Congress of Croatian Society of Medical Biochemistry and Laboratory Medicine (CSMBLM)

Mjesto i datum
Dubrovnik, Hrvatska, 10.10.2012. - 13.10.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
renal function ; liver transplantation

Sažetak
Background. Liver transplantation is accepted treatment of choice for many liver diseases. Long-term survival is limited by toxicity of immunosuppresive agents, sub-clinical as well as cronic rejection. Newer classes of immunosuppresive agents, including calcineurin inhibitors CNI (cyclosporine and tacrolimus) and mammalian target of rapamycin (mTOR) inhibitors (sirolimus and everolimus) have potential to improve long-term outcomes. Many long-term survivors face a considerable risk of renal dysfunction due to CNI. The aim of the study was to detrmine benefits of sirolimus compared to CNI towards kidneys toxicity. Materials and methods. We have monitored nine orthotopic liver transplantation patients (OLT) who underwent conversion of immunosuppresive regiment from CNIs to sirolimus. Creatinine concentrations were measured with the creatinine enzymatic assay. Measured concentrations of serum creatinine were used to estimate renal function, after dosing CNIs and converting to sirolimus, each one, three and six months after the dose. Results. Reffering to the long-term outcomes of OLT patients following results could be seen: among all patients switched to sirolimus, the levels of serum creatinine (80, 3 umol/L+/-12, 8 vs. 76, 0 umol/L+/-12, 7) remained stable in three of them, whereas the levels of serum creatinine started to decrease (119, 4 umol/L+/- 29, 8 vs. 83, 2 umol/L+/- 26, 3) after administration of sirolimus in six of the patients. Conclusion. These preliminary results have shown that sirolimus is effective in preventing rejection in OLT recipients and it is associated with improved renal function. mTOR inhibitors might have a role as an early alternative to CNIs in patients with CNI nephrotoxicity.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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