Naslov
Erythrocyte superoxide dismutase in children with bronchial obstruction

Autori
Županić, Danijela ; Čepelak, Ivana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Clinical Chemistry and Laboratory Medicine, Abstract Volume / Siest, Gerard ; Dominiczak, Marek H. - Berlin : New York : Walter de Gruyter, 1999

Skup
17th International and 13th European Congress of Clinical Chemistry and Laboratory Medicine

Mjesto i datum
Firenca, Italija, 06.06.1999. - 11.06.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
erythrocyte superoxide dismutase; broncjial obstruction; children

Sažetak
Free radicals are short life substances produced in normal biological processes or by environmental activity and are being destroyed by physiological radical-defence system. One of them is superoxide anion, product of many physiological and disease processes. Superoxide dismutase (SOD) decreases its toxicity as a part of antioxidant system. In order to measure catalytic activity of SOD in erythrocytes, we obtained blood samples from 32 children (15 girls and 17 boys, average age 9, 5+4, 7) with severe bronchial obstruction. The samples were divided into two groups: the first group contained blood samples taken from the children during the bronchial obstruction, whereas in the second group were blood samples taken five days after the medication with Salbutamol (Ventolin). Catalytic activity (U/mgHb) of SOD in erythrocytes in the group I was 0, 850+0, 334, and in the group II 0, 836+0, 364. Average increase of catalytic activity of SOD five days after treatment was 0, 204+0, 165 and its average decrease was similar 0, 206+0, 257. Since our results are not much changed by Salbutamol therapy, we determined the value of SOD in group of patients after treatment as being normal (0, 836 U/mg Hb). However, the value of SOD after Salbutamol therapy shows some differences considering the patients, sex and age.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA