Pregled bibliografske jedinice broj: 597941
Predicting the nature and timing of epimerisation on a modular polyketide synthase
Predicting the nature and timing of epimerisation on a modular polyketide synthase // ChemBioChem, 8 (2007), 1; 28-31 doi:10.1002/cbic.200600399 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 597941 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Predicting the nature and timing of epimerisation on a modular polyketide synthase
Autori
Starčević, Antonio ; Cullum, John ; Jaspars, Marcel ; Hranueli, Daslav ; Long, Paul F.
Izvornik
ChemBioChem (1439-4227) 8
(2007), 1;
28-31
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
enzymes; epimerization; erythromycin; polyketides; stereochemistry
Sažetak
Modular polyketide synthases catalyse the Claisen condensation of simple organic acids with inversion of configuration to give a 2R methyl centre. However, according to Celmer's rules, the ultimate stereochemical configuration of many polyketides requires epimerisation to the 2S isomer. It has been generally believed that the epimerisation is performed by the ketosynthase domains. We challenge this traditional thinking and propose bifunctionality of the ketoreductase domains.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
POVEZANOST RADA
Ustanove:
Prehrambeno-biotehnološki fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
