Naslov
EFFECT OF HYPERBARIC OXYGENATION AND INDOMETHACIN ON MOTOR ACTIVITY AFTER EXPERIMENTAL SPINAL CORD INJURY IN RABBITS

Autori
Simonić, Ante ; Draganić, Pero ; Nemec, Boris

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Fundamental & Clinical Pharmacology (ISSN:0767-3981), Vol 13, Suppl 1 / - : Elsevier, 1999

Skup
2nd European Congress of Pharmacology

Mjesto i datum
Budimpešta, Mađarska, 03.07.1999. - 07.07.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
spinal cord; hyperbaric oxygenation; trauma; rabbits

Sažetak
Spinal cord trauma, followed by nerve tissue damage, is an importnant medical and social problem and there is no effective drug therapy of spinal cord traumatised person. Ischemia and hypoxia, as a result of spinal cord injury, lead to the nerve tissue damage and deterioration of neural functions. Hyperbaric oxygenation (HO) is a potent reducer of tissue hypoxia, and indomethacin is a potent inhibitor of endogenous prostaglandin synthesis. It is a great imerest to test if hyperbaric oxygenation and indomethacin could protect motor activity in spinal cord contusioned animals. The study has been carried out on adult rabbits of both sexes and 2.5 - 3.5 kg body weight. A medial dorsal lumbar laminectomy was performed under pentobarbital anaesthesia ( 30 mg/kg intravenously ) using the technique of Albin and all. In some animals only laminectomy was performed, in the other animals laminectomy was followed by contusion of the spinal cord, provoked by a strike of 150 gcm. Animals that have not been submitted to the contusion of the spinal cord demonstrated spontaneously completly reversion of motor deficit. The spinal cord contusion produced a spontaneously irreversible paraplegia in the experimental animals. In all the animals motor activity has been controlled in accordance with Tarlov's system during nine posttraumatic days. Indomethacin have becn applied immediately after the conducted surgery and repeatingly during the following eight days, in the doses of 0.3; 1.0 or 3.0 mg/kg intravenously once a day. The animals have been esposed to HO immediately after the surgery and during the eight subsequent days, at 222.86 kPa pressure of 100% oxygen lasting 15 minutes. Indomethacin and hyperbaric oxygenation have shown no influence on motor activity in rabbits with non-injured spinal cord. Opposite to that HO and indomethacin improve motor activity in the traumatised animals.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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