Pregled bibliografske jedinice broj: 595181
Synthesis of halogenated 3-deazapurine and L-ascorbic acid derivatives
Synthesis of halogenated 3-deazapurine and L-ascorbic acid derivatives // ISMC 2012, XXIInd International Symposium on Medicinal Chemistry / Ortúzar, Natalia (ur.).
Berlin: Wiley-VCH, 2012. str. 378-378 (poster, međunarodna recenzija, sažetak, znanstveni)
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Naslov
Synthesis of halogenated 3-deazapurine and L-ascorbic acid derivatives
Autori
Stipković Babić, Maja ; Mintas, Mladen
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
ISMC 2012, XXIInd International Symposium on Medicinal Chemistry
/ Ortúzar, Natalia - Berlin : Wiley-VCH, 2012, 378-378
Skup
ISMC 2012, XXIInd International Symposium on Medicinal Chemistry
Mjesto i datum
Berlin, Njemačka, 02.09.2012. - 06.09.2012
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
halogenated 3-deazapurine; L-ascorbic acid
(halogenirani 3-deazapurini; L-askorbinska kiselina)
Sažetak
In research for antiviral and antitumor substances, many derivatives of natural nucleosides have been synthesized and used in treatment of viral, tumor and bacterial diseases. Numerous synthesized 3-deazapurine derivatives have shown signifficant biologial activity on the wide range of RNA and DNA viruses, broad leukemia tumor cells lines and as antituberculostatics. In light of these findings and based on our previous study, we efficiently synthesized a series of new derivatives of halogenated 3-deazapurines (A, B) and L-ascorbic (1-4, 7-8) or imino-L-ascorbic acid (5-6) as a substitute for sugar moiety to evaluate their antiviral and antitumor potency.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
125-0982464-2922 - RAZVOJ NOVIH PROLIJEKOVA I LIJEKOVA PROTIV VIRUSA I RAKA (Mintas, Mladen, MZOS ) ( CroRIS)
Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb
