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Pregled bibliografske jedinice broj: 594935

Novel Coumarin Derivatives Containing 1, 2, 4-Triazole, 4, 5-Dicyanoimidazole and Purine Moiety: Synthesis and Evaluation of Cytostatic Activity

Benci, Krešimir; Mandić, Leo; Suhina, Tomislav; Sedić, Mirela; Klobučar, Marko; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Wittine, Karlo; Mintas, Mladen
Novel Coumarin Derivatives Containing 1, 2, 4-Triazole, 4, 5-Dicyanoimidazole and Purine Moiety: Synthesis and Evaluation of Cytostatic Activity // XXIInd International Symposium on Medicinal Chemistry (ISMC 2012) : abstracts / Ortu´zar, Natalia (ur.).
Berlin: Wiley-VCH, 2012. str. 379-379 (poster, nije recenziran, sažetak, znanstveni)

CROSBI ID: 594935 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Novel Coumarin Derivatives Containing 1, 2, 4-Triazole, 4, 5-Dicyanoimidazole and Purine Moiety: Synthesis and Evaluation of Cytostatic Activity

Autori
Benci, Krešimir ; Mandić, Leo ; Suhina, Tomislav ; Sedić, Mirela ; Klobučar, Marko ; Kraljević Pavelić, Sandra ; Pavelić, Krešimir ; Wittine, Karlo ; Mintas, Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XXIInd International Symposium on Medicinal Chemistry (ISMC 2012) : abstracts / Ortu´zar, Natalia - Berlin : Wiley-VCH, 2012, 379-379

Skup
International Symposium on Medicinal Chemistry (22 ; 2012)

Mjesto i datum
Berlin, Njemačka, 02.09.2012. - 06.09.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
coumarin derivatives containing 1; 2; 4-triazole; 4; 5-dicyanoimidazole and purine moiety; cytostatic activity

Sažetak
Here, we report the synthesis and in vitro antitumor effects of a series of novel 1, 2, 4-triazole (3–6), 4, 5-dicyanoimidazole (7), and purine (8–13) coumarin derivatives and their acyclic nucleoside analogues (14–18). The structures of novel compounds 3–18 were deduced from their 1H and 13C NMR data and corresponding mass spectra. Results of an antiproliferative assay performed on a panel of selected human tumor cell lines revealed that compound 6 has moderate cytostatic activity against the HeLa cell line (IC50=35 μm), whereas compound 10 shows moderate activity against HeLa (IC50=33 μm), HepG2 (IC50=25 μm) and SW620 (IC50=35 μm) cell lines. These compounds exhibited no cytotoxic effect on normal (diploid) human fibroblasts.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA

Projekti:
335-0982464-239
125-0982464-2922 - RAZVOJ NOVIH PROLIJEKOVA I LIJEKOVA PROTIV VIRUSA I RAKA (Mintas, Mladen, MZOS ) ( CroRIS)
335-0000000-3532 - Uloga IGF2 i signalni putovi nizvodno u karcinomima pluća čovjeka (Peter-Katalinić, Jasna, MZOS ) ( CroRIS)

Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Sveučilište u Rijeci - Odjel za biotehnologiju

Profili:

Avatar Url Mirela Sedić (autor)

Avatar Url Sandra Kraljević Pavelić (autor)

Avatar Url Mladen Mintas (autor)

Avatar Url Leo Mandić (autor)

Avatar Url Krešimir Pavelić (autor)

Avatar Url Krešimir Benci (autor)

Avatar Url Marko Klobučar (autor)

Avatar Url Karlo Wittine (autor)

Citiraj ovu publikaciju:

Benci, Krešimir; Mandić, Leo; Suhina, Tomislav; Sedić, Mirela; Klobučar, Marko; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Wittine, Karlo; Mintas, Mladen
Novel Coumarin Derivatives Containing 1, 2, 4-Triazole, 4, 5-Dicyanoimidazole and Purine Moiety: Synthesis and Evaluation of Cytostatic Activity // XXIInd International Symposium on Medicinal Chemistry (ISMC 2012) : abstracts / Ortu´zar, Natalia (ur.).
Berlin: Wiley-VCH, 2012. str. 379-379 (poster, nije recenziran, sažetak, znanstveni)
Benci, K., Mandić, L., Suhina, T., Sedić, M., Klobučar, M., Kraljević Pavelić, S., Pavelić, K., Wittine, K. & Mintas, M. (2012) Novel Coumarin Derivatives Containing 1, 2, 4-Triazole, 4, 5-Dicyanoimidazole and Purine Moiety: Synthesis and Evaluation of Cytostatic Activity. U: Ortu´zar, N. (ur.)XXIInd International Symposium on Medicinal Chemistry (ISMC 2012) : abstracts.
@article{article, author = {Benci, Kre\v{s}imir and Mandi\'{c}, Leo and Suhina, Tomislav and Sedi\'{c}, Mirela and Klobu\v{c}ar, Marko and Kraljevi\'{c} Paveli\'{c}, Sandra and Paveli\'{c}, Kre\v{s}imir and Wittine, Karlo and Mintas, Mladen}, editor = {Ortu´zar, N.}, year = {2012}, pages = {379-379}, keywords = {coumarin derivatives containing 1, 2, 4-triazole, 4, 5-dicyanoimidazole and purine moiety, cytostatic activity}, title = {Novel Coumarin Derivatives Containing 1, 2, 4-Triazole, 4, 5-Dicyanoimidazole and Purine Moiety: Synthesis and Evaluation of Cytostatic Activity}, keyword = {coumarin derivatives containing 1, 2, 4-triazole, 4, 5-dicyanoimidazole and purine moiety, cytostatic activity}, publisher = {Wiley-VCH}, publisherplace = {Berlin, Njema\v{c}ka} }
@article{article, author = {Benci, Kre\v{s}imir and Mandi\'{c}, Leo and Suhina, Tomislav and Sedi\'{c}, Mirela and Klobu\v{c}ar, Marko and Kraljevi\'{c} Paveli\'{c}, Sandra and Paveli\'{c}, Kre\v{s}imir and Wittine, Karlo and Mintas, Mladen}, editor = {Ortu´zar, N.}, year = {2012}, pages = {379-379}, keywords = {coumarin derivatives containing 1, 2, 4-triazole, 4, 5-dicyanoimidazole and purine moiety, cytostatic activity}, title = {Novel Coumarin Derivatives Containing 1, 2, 4-Triazole, 4, 5-Dicyanoimidazole and Purine Moiety: Synthesis and Evaluation of Cytostatic Activity}, keyword = {coumarin derivatives containing 1, 2, 4-triazole, 4, 5-dicyanoimidazole and purine moiety, cytostatic activity}, publisher = {Wiley-VCH}, publisherplace = {Berlin, Njema\v{c}ka} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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