Naslov
Development of pectine-based mucoadhesive patches for buccal delivery of triclosan: effect of cyclodextrin complexation

Autori
Jug, Mario ; Maestrelli, Francesca ; Mura, Paola

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XXII Simposio A.D.R.I.T.E.L.F. 40 anni di Technologia Farmaceutica: Programma e Abstracts / Alhaique, Franco - Firenza : München : UniFi, 2012, 102-102

Skup
XXII Simposio A.D.R.I.T.E.L.F.

Mjesto i datum
Firenca, Italija, 13.09.2012. - 16.09.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
triclosan; polymeric cyclodextrin derivatives; buccal delivery

Sažetak
Elimination of cariogenic bacteria from dental film is an important step in prevention and treatment of dental conditions and of related systemic diseases. Triclosan (TR), a broad spectrum antibacterial agent, is a possible candidate for this aim. However, to obtain effective TR levels in the oral cavity, there is the need of developing a suitable formulation allowing both a prolonged in situ residence and a controlled drug release. The design of such formulation is a particularly challenging issue for a poorly soluble drug as TR, due to the limited amount of saliva in the mouth, acting as dissolution medium. Based on these premises, we considered it worthy of interest to develop a TR mucoadhesive buccal formulation, by using pectin-Carbopol combinations as mucoadhesive matrix-forming polymer, and exploiting cyclodextrin (CD) complexation (with polymeric or native ßCD) for improving drug solubility and optimising its release rate from the matrix. Phase-solubility studies were performed to determine the solubilizing efficiency of the different CDs towards TR and evaluate the effect of pectin addition. Erosion, swelling and mucoadhesion studies allowed selection of the best pectin-Carbopol ratio and investigation of the effect of drug loading, both alone or as CD complex. CD complexation markedly enhanced the in vitro drug release rate from buccal patches. However, in the case of TR/βCD complex, the drug release rate was sensitive upon the hydration degree of the matrix, showing a biphasic release profile. On the contrary, patches loaded with TR/polymericβCD complex showed a constant drug release, according to a zero-order kinetic, which is a desirable property for a controlled release formulation. Environmental electron microscopy, used to analyse the microstructure and surface topography of patches prior and after release test, enabled to gain a deeper insight into phenomena occurring during drug release.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA