Pregled bibliografske jedinice broj: 594414
Impact of gene polymorphisms on the formation of abdominal aortic aneurysm in humans
Impact of gene polymorphisms on the formation of abdominal aortic aneurysm in humans // 11th Croatian Biological Congress with International Participation - Proceedings of Abstracts / Jelaska, Sven ; Klobučar, Goran ; Šerić Jelaska, Lucija ; Leljak Levanić, Dunja ; Lukša, Žaklin (ur.).
Zagreb: Hrvatsko biološko društvo, 2012. str. 126-127 (pozvano predavanje, domaća recenzija, sažetak, znanstveni)
CROSBI ID: 594414 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Impact of gene polymorphisms on the formation of abdominal aortic aneurysm in humans
(Utjecaj genskih polimorfizama na nastanak aneurizme trbušne aorte u ljudi)
Autori
Dabelić, Sanja ; Crkvenac Gregorek Andrea ; Crkvenac Gornik Kristina ; Stupin Polančec Darija
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
11th Croatian Biological Congress with International Participation - Proceedings of Abstracts
/ Jelaska, Sven ; Klobučar, Goran ; Šerić Jelaska, Lucija ; Leljak Levanić, Dunja ; Lukša, Žaklin - Zagreb : Hrvatsko biološko društvo, 2012, 126-127
Skup
11th Croatian Biological Congress with International Participation
Mjesto i datum
Šibenik, Hrvatska, 16.09.2012. - 21.09.2012
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Domaća recenzija
Ključne riječi
abdominal aortic aneurysm ; polymorphism
(aneurizma abdominalne aorte ; polimorfizmi)
Sažetak
Abdominal aortic aneurysm (AAA) is a complex genetic disorder, caused by unfavorable interplay of different genetic and environmental risk factors. DNA was isolated from blood samples of 234 Croatian individuals (117 with AAA and 117 healty controls). The allelic and genotype frequency of five polymorphism were determined: the number of (GT)n dinucleotide repeats in the heme oxygenase-1 gene promoter (HO-1), the deletion of 32 bp in the chemokine receptor 5 gene (CCR5), insertion/deletion of 287 bp in the angiotensin-converting enzyme (ACE) gene as well as two single nucleotide polymorphisms - in the angiotensin II type 1 receptor gene (SNP 1166A>C AT1R) and in the matrix metalloproteinase-9 gene (SNP -1562C>T MMP-9). Carriers of ACE DD genotype and MMP-9 -1562 TT genotype showed increased risk for developing AAA. Decreased risk for the developing showed carriers of HO-1 LL genotype, while other two polymorphisms were not associated with AAA. For the first time, Croatian subjects were genotyped for (GT)n HO-1 and SNP-1562C>T MMP-9.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Kliničke medicinske znanosti, Farmacija
POVEZANOST RADA
Projekti:
006-0061194-1218 - Glikobiološki aspekti stanične prilagodbe i komunikacije (Dumić, Jerka, MZOS ) ( CroRIS)
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb
