Efficient palladium-mediated or base-induced 5-endo-dig cyclisation of C5-alkynylated pyrimidine derivatives: conventional and microwave-assisted synthesis of novel furo[2,3-d]pyrimidines

Gazivoda Kraljević, Tatjana; Bistrović, Andrea; Dedić, Matea; Kraljević Pavelić, Sandra; Sedić, Mirela; Raić-Malić, Silvana

doi:10.1016/j.tetlet.2012.07.068

Pregled bibliografske jedinice broj: 594393

Efficient palladium-mediated or base-induced 5-endo-dig cyclisation of C5-alkynylated pyrimidine derivatives: conventional and microwave-assisted synthesis of novel furo[2,3-d]pyrimidines

Gazivoda Kraljević, Tatjana; Bistrović, Andrea; Dedić, Matea; Kraljević Pavelić, Sandra; Sedić, Mirela; Raić-Malić, Silvana

Efficient palladium-mediated or base-induced 5-endo-dig cyclisation of C5-alkynylated pyrimidine derivatives: conventional and microwave-assisted synthesis of novel furo[2,3-d]pyrimidines // Tetrahedron letters, 53 (2012), 38; 5144-5147 doi:10.1016/j.tetlet.2012.07.068 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 594393 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Efficient palladium-mediated or base-induced 5-endo-dig cyclisation of C5-alkynylated pyrimidine derivatives: conventional and microwave-assisted synthesis of novel furo[2,3-d]pyrimidines

Autori
Gazivoda Kraljević, Tatjana ; Bistrović, Andrea ; Dedić, Matea ; Kraljević Pavelić, Sandra ; Sedić, Mirela ; Raić-Malić, Silvana

Izvornik
Tetrahedron letters (0040-4039) 53 (2012), 38; 5144-5147

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
5-alkynylpyrimidines ; furo[2, 3-d]pyrimidines ; N-methoxymethylated pyrimidine derivatives ; Sonogashira cross-coupling reaction ; 5-endo-dig cyclisation

Sažetak
A series of the novel 5-alkynyl- and furo[2, 3-d]pyrimidine derivatives in which the sugar moiety is replaced by a methoxymethyl (MOM) group is synthesised using the Sonogashira cross-coupling reaction under both conventional and microwave conditions, in good to excellent yields. The 5-endo-dig cyclisation of 5-alkynylpyrimidine derivatives promoted by a Pd-catalyst or base gives the corresponding furo[2, 3-d]pyrimidines in good yields.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA

Projekti:
MZOS-125-0982464-2925 - Razvoj i primjena novih molekula u pozitron-emisijskoj tomografiji (PET) (Raić-Malić, Silvana, MZOS ) ( CroRIS)
MZOS-335-0000000-3532 - Uloga IGF2 i signalni putovi nizvodno u karcinomima pluća čovjeka (Peter-Katalinić, Jasna, MZOS ) ( CroRIS)

Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Sveučilište u Rijeci - Odjel za biotehnologiju

Profili:

Mirela Sedić (autor)