Naslov
Process development of fully integrated hexanal production in microchannel

Autori
Ivanković, Mia ; Šalić, Anita ; Zelić, Bruno

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts "Applied Biocatalysis" 8th meeting of students and university professors / Vrsalović Presečki, A ; Vasić-Rački, Đ - Zagreb : Fakultet kemijskog inženjerstva i tehnologije Sveučilišta u Zagrebu, 2012, 11-11

ISBN
978-953-6470-59-4

Skup
"Applied Biocatalysis" 8th meeting of students and university professors

Mjesto i datum
Zagreb, Hrvatska, 19.09.2012

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ADH; hexanal; microreactor; fully integrated process

Sažetak
Hexanal is an essential part of the group of easily volatile components known as "green notes". Because of its organoleptic properties hexanal has found wide application in food, pharmaceutical and cosmetic industries, and due to its bactericidal and fungicidal properties is applied in agriculture. Normally it is produced by fermentation with whole cells and enzyme-catalyzed reactions or extracted from plants. The main disadvantages of these processes are low yields, formation of undesired by-products and the formation of large amounts of waste, so the need for development and application of new technologies in the production of hexanal is more than obvious. As one of the new technologies used in the production of hexanal, microreactor systems are increasingly being imposed as they allow better transfer of matter and energy, lower consumption of chemicals and energy, and other advantages over conventional reactors. In this work biocatalytic oxidation of hexanol with the enzyme alcohol dehydrogenase in 6 μL microreactor was carried out. Alcohol dehydrogenase is an enzyme that belongs to the group of oxidoreductases which share the characteristics of the need for coenzyme. As the price of coenzyme NAD+ is extremely high, it is necessary to regenerate a reduced form of coenzyme into the oxidized form. Therefore hexanal production process with fully integrated regeneration and recirculation of coenzyme in two serially connected microchips was developed. Mass transfer between the two phases established in microchannel was analysed and corresponding mathematical model of 2D flow was developed. Additionaly, mathematical model of a fully integrated hexanal production process with coenzyme regeneration in microreactor was developed. Validation of the model was performed using data from independent experiments. The good agreement between simulation and experimental results was observed.

Izvorni jezik
Engleski

Znanstvena područja
Kemijsko inženjerstvo, Biotehnologija

POVEZANOST RADA