Naslov
Comparative in vitro antimicrobial activity of various flavonoids

Autori
Kropek, Ana ; Kropek, Matija ; Vladimir-Knežević, Sanda

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts - 13th Congress of the International Society for Ethnopharmacology / Bauer, Rudolf - Graz, 2012, 203-203

Skup
13th Congress of the International Society for Ethnopharmacology

Mjesto i datum
Graz, Austrija, 02.09.2012. - 06.09.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
flavonoids; antimicrobial activity

Sažetak
Many infectious diseases have been known to be treated with herbal remedies throughout the history of mankind. Natural products, either as pure compounds or as standardized plant extracts, provide an almost unlimited potential for search of novel drugs. Flavonoids are a large group of plant secondary metabolites with potentially exploitable antimicrobial activities and this class of natural products is increasingly becoming the subject of anti-infective research. In this work in vitro antimicrobial activity of 17 flavonoid aglycones from different subclasses as well as six medicinal plant extracts containing flavonoids was estimated by microdilution broth assay. Candida albicans ATCC 10231 showed the highest sensitivity to the majority of tested flavonoids (MICs 0.01-1.00 mg/mL) and plant extracts (MICs 0.63-1.25 mg/mL). Among the investigated flavonoids found to be effective against Staphylococcus aureus ATCC 6538, myricetin and isoliquiritigenin were considered to be most potent (MIC 0.25 mg/mL). Chalcone isoliquiritigenin also demonstrated the strongest antibacterial effect against Escherichia coli ATCC 8739 (MIC 0.50 mg/mL). Our results provided additional evidence of antimicrobial activity of various flavonoids and highlighted some promising candidates for future research.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA