Naslov
Structure analysis of proteins, peptides and metal complexes by vibrational circular dichroism

Autori
Hollósi, Miklós ; Vass, Elemér ; Szilvágyi, Gábor ; Jakas, Andreja ; Laczkó, Ilona

Izvornik
ARKIVOC (1551-7004) (2012), 5; 291-300

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
vibrational circular dichroism (VCD); determination of absolute configuration; characterization of protein conformation; structure analysis of cyclic peptides; VCD of glycopeptides and chiral transition metal complexes

Sažetak
There are two principal forms of vibrational optical activity (VOA), an IR form referred to as vibrational circular dichroism (VCD) and Raman form known as Raman optical activity (ROA). This paper reports examples of the application of VCD spectroscopy for the determination of the absolute configuration and conformation of chiral molecules, e.g. cyclic β-lactams. VCD spectroscopy can be applied for the characterization of the conformation of proteins and peptides in solution. VCD based conformational analysis of cyclic peptides is discussed. Examples are the cyclic hexapeptide cyclo(Pro2-Gly-Pro2-Gly) and cyclic peptides comprising β-homoamino acids (trans-2-aminocyclopentane or trans-2-aminocyclohexane carboxylic acid). Structure analysis by VCD of opiate peptides, glycopeptides, peptidomimetics and chiral transition metal complexes are also discussed.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA