Naslov
The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides

Autori
Sikirić, Predrag ; Seiwerth, Sven ; Grabarević, Željko ; Petek, Marijan ; Ručman, Rudolf ; Turković, Branko ; Rotkvić, Ivo ; Jagić, Vjekoslav ; Duvnjak, Marko ; Miše, Stjepan ; Đačić, Sanja ; Šeparović, Jadranka ; Veljača, Marija ; Sallmani, A. ; Banić, Marko ; Brkić, Tomislav

Izvornik
Life sciences (0024-3205) 54 (1994), 5; 63-68

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo, znanstveni

Ključne riječi
pentadecapeptide BPC 157

Sažetak
The protection of stomach and duodenum in conjecture with anti-inflammatory effect was demonstrated for a novel 15 amino acid peptide, coded BPC 157, a fragment of the recently discovered gastric juice peptide BPC. BPC 157 (i.p./i.g.) was investigated in rats in comparison with several reference standards in three experimental ulcer models (48 h-restraint stress, subcutaneous cysteamine, intragastrical 96% ethanol ulcer tests) (pre-/co-/post-treatment). Only BPC 157 regimens were consistently effective in all of the tested models. On the other hand, bromocriptine, amantadine, famotidine, cimetidine and somatostatin were ineffective (restraint stress). A dose-dependent protection (cysteamine) and/or partial positive effect (related to treatment conditions) (ethanol), was obtained with glucagon, NPY and secretin whereas CCK/26-30/was not effective. Based on Monastral blue studies BPC 157 beneficial effect appears to be related to a strong endothelial protection.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA