Naslov
Biologically active benzimidazoles and benzimidazo[1, 2-a]quinolines

Autori
Hranjec, Marijana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of The 4th Young Investigators Workshop (EuCheMS) / Mihovilović, M. D. ; Schnurch, M. ; Siegel, J. - Beč : Institute of Applied Synthetic Chemistry, Vienna University of Technology, 2012, 26-26

Skup
Young Investigators Workshop (4 ; 2012)

Mjesto i datum
Beč, Austrija, 23.08.2012. - 26.08.2012

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
benzimidazoles; benzimidazo[1; 2-a]quinolines

Sažetak
The permanent and growing interest in the synthesis of benzimidazole and their azino fused derivatives, as a one of the most extensively studied classes of heterocyclic compounds, is a direct consequence of their diverse biological properties. Because of their structural similarity with some naturally occurring compounds, a variety of derivatives play a crucial role in the function of some biologically important molecules or can easily interact with biomolecules like DNA, RNA or different proteins of the living systems. Recently, as a part of our continues scientific research in the field of potential, biologically active benzimidazoles, we have reported on the synthesis and biological activity of several groups of 2-styryl substituted benzimidazoles and benzimidazo[1, 2-a]quinolines and their heteroaromatic analogues, including positively charged amidino and amino substituted derivatives. , , Biological studies confirmed the strong anticancer potential of this class of compounds while DNA/RNA binding studies revealed intercalation into ds DNA or RNA, especially of positively charged amidino substituted benzimidazo[1, 2-a]quinolines. Due to high fluorescence intensity and excellent spectroscopic characteristics, fused benzimidazoles offer also a potential application as fluorescent probes for detection of biological important molecules in biomedical diagnostics or as chemosensors that are capable of assaying cations in solution.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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