Pregled bibliografske jedinice broj: 591619
Quinone methides: photochemical generation and its application in biomedicine
Quinone methides: photochemical generation and its application in biomedicine // Current organic chemistry, 18 (2014), 1; 3-18 doi:10.2174/138527281801140121122330 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 591619 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Quinone methides: photochemical generation and its application in biomedicine
Autori
Basarić, Nikola ; Mlinarić-Majerski, Kata ; Kralj, Marijeta
Izvornik
Current organic chemistry (1385-2728) 18
(2014), 1;
3-18
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
DNA alkylating agents ; DNA cross-linking ; excited-state intramolecular proton transfer (ESIPT) ; photo-deammination ; photo-dehydration ; quinone methides
Sažetak
Quinone methides (QMs) are important intermediates in chemistry and biochemistry of phenols that are characterized by wide biological activity. Some classes of anticancer antibiotics exhibit their effect due to methabolic formation of QMs that alkylate DNA. Photochemical reactions provide mild and easy approach to QMs. Photoreactions that give QMs include cleavage of oxa-heterocycles, dehydrohalogenation, dehydration, deammination, excited state intramolecular proton transfer (ESIPT) and tautomerizations of phenols. This critical review (137 references) features different photochemical reactions giving QMs that are applicable in biology and medicine.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Temeljne medicinske znanosti
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
