Pregled bibliografske jedinice broj: 589775
S-adenosylhomocysteine hydrolase (AHCY )deficiency: A natural model system for methylation research
S-adenosylhomocysteine hydrolase (AHCY )deficiency: A natural model system for methylation research // Rad 508: Medical Sciences, 35 (2010), 77-92 (podatak o recenziji nije dostupan, pregledni rad, znanstveni)
CROSBI ID: 589775 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
S-adenosylhomocysteine hydrolase (AHCY )deficiency: A natural model system for methylation research
Autori
Belužić, Robert ; Vugrek, Oliver
Izvornik
Rad 508: Medical Sciences (1330-5301) 35
(2010);
77-92
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
methylation disorder; metabolic disease; genotype-phenotype; homocysteine; human mutation; S-Adenosylmethionine (SAM); S-Adenosylmethionine (SAM); S-Adenosylhomocysteine- hydrolase (AHCY)
Sažetak
AHCY deficiency is a new human methylation disorder, discovered recently in Croatia, and a natural model for investigating processes related to the methylome. Methylation plays an important role in regulating biological processes and is crucial for gene expression, imprinting, signalling, protein synthesis and lipid metabolism. Thus, methylation has broad impact and provides a suitable base for interdisciplinary research. Linking genomics, proteomics, cellomics, lipidomics and metabolomics and other omics approaches may create a new research avenue – ‘AHCYdomics’ - a new methylation research platform based on AHCY deficiency. Using such research platform will allow to efficiently explore the full potential of the human methylation disorder AHCY deficiency, and to design methods and approaches that will lead to a better understanding of the human methylome.
Izvorni jezik
Engleski
