Naslov
Lysosome alterations influenced by copper intoxication

Autori
Kralj-Klobučar, Nada

Izvornik
Pharmacology & Toxicology (0901-9928) 80 (1997), 3;

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
carp; lysosomes; copper intoxication; AAS analysis

Sažetak
Carp (Cyprinus carpio L.) were treated with constant concentrations of 0,1 mg/L of copper during the period of 49 days, and the tissue samples were taken in the intervals of seven days. By the means of AAS analysis, the results have shown that the concentrations of copper in the liver were increasing during the treatment, from the 3,38 mg/L in the beginning up to the 18,2 mg/g after the six weeks. In the 6th week of contamination, by the sulphide-silver method, the Cu can be located in the isolated perinuclearylocated granules. By the histochemical methods for establishing the activity of acid phosphatase, it was shown that the density of lysosom have increased, and some lysosomes have increased in volume. The results are in accordance with thw image-analyser measurments, which have shown the number of lysosomes, as well as the area they covered, during the treatment is increased.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA